Northeast Missouri Vacations from $251
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Your Northeast Missouri Vacation
When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Center and Busch Stadium. St. Charles is another top city that draws travelers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.
The Latest Northeast Missouri vacation packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Save 100% on your flight
Price was $669, price is now $508 per person
$508
per person
Dec 3 - Dec 7
found 20 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,010 reviews)
The Cheshire Inn is such a great, unique hotel - we loved our first stay here! We came in for WashU parents' weekend and stayed two nights. Very well-appointed hotel, super cute decorations and theme, very clean and tidy. The bar is a nice spot for a cocktail or draft beer and the lobby and sitting areas are spacious and comfy. Free breakfast was a very nice amenity. We very much look forward to staying at the Cheshire again in the future!
Reviewed on Nov 3, 2026
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View all tripsWhere to stay in Northeast Missouri
Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. Learn more about Northeast Missouri
Clayton
1 out of top 10 points of interest in this area
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Stay near popular Northeast Missouri attractions
What to do in Northeast Missouri
Kansas City Haunted Pub Crawl Ghostly Drinks and Stories
$35
per adult
Astounding Scavenger Hunt: Fountains, Fun & Hidden Finds
$15
per adult
Northeast Missouri Hotel Deals
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $106 total per night from Nov 8 to Nov 9
$106 total
Nov 8 - Nov 9
Total with taxes and fees
9.4/10 Exceptional! (3,344 reviews)
"Check inout Staff was amazing"
Reviewed on Nov 3, 2026
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $123 total per night from Nov 8 to Nov 9
$123 total
Nov 8 - Nov 9
Total with taxes and fees
8.8/10 Excellent! (3,525 reviews)
"My room looked clean and I'm glad I sprayed everything down because after a while I saw a bed bug on the bed. It stopped where I sprayed lysol on the bed and I sprayed it again and I think it died. I took a picture, got my stuff and left. I payed for the executive suite on my birthday and a bed bug ..."
Reviewed on Nov 2, 2026
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Nov 29 to Nov 30
$105 total
Nov 29 - Nov 30
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Northeast Missouri Vacation Packages
Northeast Missouri Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.