Northeast Missouri Vacations from $379

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Your Northeast Missouri Vacation

When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Center and Busch Stadium. St. Charles is another top city that draws travelers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.

The Latest Northeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.
The Knight Center at Washington University
The Cheshire
Moonrise Hotel
 The Royal Sonesta Chase Park Plaza St. Louis
Ameristar Casino Resort and Spa
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Where to stay in Northeast Missouri

Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. Learn more about Northeast Missouri

Discover the most popular places to visit in Northeast Missouri

What to do in Northeast Missouri

Northeast Missouri Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $115 total per night from Jun 7 to Jun 8
$115 total
Jun 7 - Jun 8
Total with taxes and fees
7.8/10 Good! (1,339 reviews)
"It took 25 minutes to check in because only 1 person at desk at 3pm. We stayed in room 137. There was a strange loud thumping sound in pipes. I told front desk, she said no maintenance until Monday. It kept me up for long time. Next morning at check out the clerk said they KNEW there is an issue, ..."

Reviewed on Jun 6, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $116 total per night from Jun 7 to Jun 8
$116 total
Jun 7 - Jun 8
Total with taxes and fees
9/10 Wonderful! (3,222 reviews)
"What we most liked about the hotel was the free, convenient parking and the perfect location near those we were visiting. The area is lovely and walkable. Our room was adequately sized. The bathroom shower seemed recently upgraded with digital controls. There were coffee packets in the room, but ..."

Reviewed on Jun 6, 2026

Clayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from Jun 11 to Jun 12
$143 total
Jun 11 - Jun 12
Total with taxes and fees
8.8/10 Excellent! (2,002 reviews)
"The staff was amazing & we had a nice stay for the night."

Reviewed on Jun 5, 2026

Pear Tree Inn St. Louis Near Union Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Northeast Missouri Vacation Packages

Northeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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