Northeast Missouri Vacations from $393

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Your Northeast Missouri Vacation

When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Center and Busch Stadium. St. Charles is another top city that draws travelers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.

The Latest Northeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
The Wildwood Hotel
The Cheshire
Ameristar Casino Resort and Spa
DoubleTree by Hilton Hotel St. Louis - Chesterfield
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Where to stay in Northeast Missouri

Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. Learn more about Northeast Missouri

Discover the most popular places to visit in Northeast Missouri

What to do in Northeast Missouri

Northeast Missouri Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $115 total per night from Jun 2 to Jun 3
$115 total
Jun 2 - Jun 3
Total with taxes and fees
7.8/10 Good! (1,320 reviews)
"From the outside looking in, the property looked really nice. When we checked in, the toilet didn't work. The front desk said the maintenance person was gone but they could bring me a plunger. They never did. When we went to take a shower in the morning, we noticed blood stains on the bathroom walls. ..."

Reviewed on Jun 1, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $141 total per night from Jun 14 to Jun 15
$141 total
Jun 14 - Jun 15
Total with taxes and fees
Pear Tree Inn St. Louis Near Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Jun 14 to Jun 15
$111 total
Jun 14 - Jun 15
Total with taxes and fees
9/10 Wonderful! (3,224 reviews)
"No bottled water in room. Take your own if you expect that sort of thing."

Reviewed on Jun 1, 2026

Clayton Plaza Hotel & Extended Stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Northeast Missouri Vacation Packages

Northeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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